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Synthesis and antitumor evaluation of analogues of the marine pyrroloiminoquinone tsitsikammamines
Rives, A.; Le Calvé, B.; Delaine, T.; Legentil, L.; Kiss, R.; Delfourne, E. (2010). Synthesis and antitumor evaluation of analogues of the marine pyrroloiminoquinone tsitsikammamines. Eur. J. Med. Chem. 45(1): 343-351. http://dx.doi.org/10.1016/j.ejmech.2009.10.019
In: European Journal of Medicinal Chemistry. Elsevier: Amsterdam. ISSN 0223-5234; e-ISSN 1768-3254
Peer reviewed article  
Available in  Authors 
    Vlaams Instituut voor de Zee: Open Marine Archive 292098 [ download pdf ]
Keyword
    Marine/Coastal
Author keywords
    Marine alkaloid; Pyrroloiminoquinone; Tsitsikammamine; Antitumoractivity
Authors  Top 
  • Rives, A.
  • Le Calvé, B.
  • Delaine, T.
  • Legentil, L.
  • Kiss, R.
  • Delfourne, E.
Abstract
    Two series of analogues of the marine pyrroloiminoquinone alkaloids tsitsikammamine have been synthesized on the basis of a Michael addition between 2'-amino-1-(4-methoxyphenyl)-ethanol and two indolediones. All the compounds were evaluated in vitro for anti proliferative activity against distinct cancer cell lines.
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